[HTML][HTML] The interactions of monomeric acridines and unsymmetrical bisacridines (UAs) with DNA duplexes: an insight provided by NMR and MD studies
T Laskowski, M Kosno, W Andrałojć, JE Frackowiak… - Scientific Reports, 2023 - nature.com
… Additionally, their anticancer activity was enhanced when bound to quaternary quantum dots…
action of cytotoxic and antitumor 1-nitroacridines. III. In vivo interstrand cross-linking of DNA …
action of cytotoxic and antitumor 1-nitroacridines. III. In vivo interstrand cross-linking of DNA …
Cytotoxicity, crosslinking and biological activity of three mitomycins
SY Cheng, L Delgado-Cruzata, CC Clement… - Bioorganic …, 2022 - Elsevier
… intrastrand crosslinks in reactions with DNA, however, the scientific consensus is that ICLs
are the major cytotoxic … cell lines, our results suggest that the cytotoxicity of mitomycins toward …
are the major cytotoxic … cell lines, our results suggest that the cytotoxicity of mitomycins toward …
A new 1-nitro-9-aminoacridine derivative targeting yeast topoisomerase II able to overcome fluconazole-resistance
K Rząd, E Paluszkiewicz, I Gabriel - Bioorganic & Medicinal Chemistry …, 2021 - Elsevier
… acridone derivatives with anticancer activity are reported to be … therapeutic index and low
cytotoxicity with potential for clinical … The synthesis of symmetrical bis-1-nitroacridines IE7–IE10 …
cytotoxicity with potential for clinical … The synthesis of symmetrical bis-1-nitroacridines IE7–IE10 …
[HTML][HTML] Metabolic profiles of new unsymmetrical bisacridine antitumor agents in electrochemical and enzymatic noncellular systems and in tumor cells
A Mieszkowska, AM Nowicka, A Kowalczyk, A Potęga… - Pharmaceuticals, 2021 - mdpi.com
… -1-nitroacridines were also developed as antitumor … therapeutic efficacy and the adverse
side effects, both resulting from … in our laboratory, expressed significantly higher cytotoxicity …
side effects, both resulting from … in our laboratory, expressed significantly higher cytotoxicity …
[HTML][HTML] Chloroacridine derivatives as potential anticancer agents which may act as tricarboxylic acid cycle enzyme inhibitors
M Cichorek, A Ronowska, K Dzierzbicka… - Biomedicine & …, 2020 - Elsevier
… This paper concerns the cytotoxicity of 9-chloro-1-… According to our knowledge, the anticancer
activity of these … ligand and its DNA binding site and as such could influence the biological …
activity of these … ligand and its DNA binding site and as such could influence the biological …
[HTML][HTML] Targeting DNA topoisomerase II in antifungal chemotherapy
… the active tyrosine further from the DNA and thus reduce its ability to cleave DNA. P437L
mutation played a crucial role in deciphering the mechanism involved in ATP-dependent …
mutation played a crucial role in deciphering the mechanism involved in ATP-dependent …
Targeting DNA Topoisomerase II in Antifungal Chemotherapy
K Kondaka, I Gabriel - Molecules - europepmc.org
… the active tyrosine further from the DNA and thus reduce its ability to cleave DNA. P437L
mutation played a crucial role in deciphering the mechanism involved in ATP-dependent …
mutation played a crucial role in deciphering the mechanism involved in ATP-dependent …